Pharmocokinetic model-controlled infusion of midazolam.

Pharmacokinetics Alterations of Midazolam Infusion versus Bolus Administration in Mechanically Ventilated Critically Ill Patients

There is no randomized study carried out in order to compare their pharmacokinetic parameters although midazolam, as a sedative, has been widely administered via continuous infusion as well as intermittent bolus doses in mechanically ventilated critically ill patients. We prospectively investigated the effect of these two principal methods on pharmacokinetic parameters in 23 of mentioned patien...

Infusion of midazolam in paediatric patients after cardiac surgery.

Midazolam was given, by infusion, for the sedation of 10 children receiving intensive care after cardiac surgery. Plasma concentrations greater than 250 ng ml-1 were required for adequate sedation. Midazolam did not cumulate in eight of the 10 children, and these patients excreted the drug in a fashion similar to that by adults. However, midazolam did accumulate in two children, one with profou...

Pharmacokinetics Alterations of Midazolam Infusion versus Bolus Administration in Mechanically Ventilated Critically Ill Patients

There is no randomized study carried out in order to compare their pharmacokinetic parameters although midazolam, as a sedative, has been widely administered via continuous infusion as well as intermittent bolus doses in mechanically ventilated critically ill patients. We prospectively investigated the effect of these two principal methods on pharmacokinetic parameters in 23 of mentioned patien...

High-dose midazolam infusion for refractory status epilepticus.

OBJECTIVE This study compares 2 treatment protocols allowing low vs high continuous IV midazolam (cIV-MDZ) doses. METHODS We compared adults with refractory status epilepticus treated with a protocol allowing for high-dose cIV-MDZ (n = 100; 2002-2011) with those treated with the previous lower-dose cIV-MDZ (n = 29; 1996-2000). We collected data on baseline characteristics, cIV-MDZ doses, seiz...

Target Controlled Infusion (TCI)